Interaction of ligands such as epidermal growth factor and interferon‐γ with the extracellular domains of their plasma membrane receptors results in internalization followed by translocation into the nucleus of the ligand and/or receptor. There has been reluctance, however, to ascribe signaling importance to this, the focus instead being on second messenger pathways, including mobilization of kinases and inducible transcription factors (TFs). The latter, however, fails to explain the fact that so many ligands stimulate the same second messenger cascades/TFs, and yet (...) show distinct gene activation profiles. This is particularly apt in the case of the seven STAT TFs that are held to be the mediators of the distinct cellular functions of over 60 ligands. The current review focuses on five representative nuclear localizing ligands for which there is documentation of translocation into the cytosol and nucleus through well‐characterized pathways, in addition to a role in gene activation by ligand/receptor in the nucleus. BioEssays 26:993‐1004, 2004. © 2004 Wiley Periodicals, Inc. (shrink)

Is the market civilizing or destructive? The increased salience of science commercialization is forcing scientists to address this question. Benefiting from the sociology of morality literature’s increased attention to specific kinds of morality and engaging with economic sociology’s moral markets literature, we generate competing hypotheses about scientists’ value-driven attitudes toward patenting. The Civilizing Market thesis suggests scientists who prioritize universalism will tend to support patenting. The Destructive Market thesis, by contrast, suggests universalism will be correlated with opposition to patenting. We (...) analyze survey data from biologists and physicists nested within academic organizations, which are nested within the following regions: France, Hong Kong, India, Italy, Taiwan, Turkey, UK, and the USA. Employing multilevel analysis, we find correlational evidence to support the Destructive Market thesis. Universalism is associated with anti-patenting attitudes, suggesting scientists expect patenting to have deleterious effects on science and society. We end with a discussion of this article’s implications for the moral markets literature, sociology of morality and business ethics. (shrink)

Entrepreneurs of contested commodities often face stakeholders engaged in market excluding boundary work driven by ethical considerations. For example, the conversion of academic scientific knowledge into technologies that can be owned and sold is a growing global trend and key stakeholders have different ethical responses to this contested commodity. Commercialization of science can be viewed as a good thing because people believe it bolsters economic growth and broadly benefits society. Others view it as bad because they believe it discourages basic (...) research that ought to be freely shared without concern for profit. Taking a descriptive sociological approach, we posit that the stance of a religious tradition toward capitalism will help shape individual scientists’ views on science commercialization and test whether the religious tradition of scientists correlates with their attitude toward the commercialization of science. To maximize variance on the religious tradition dimension, we analyze pooled data from a cross-national survey of university biologists and physicists encompassing France, Hong Kong, India, Italy, Taiwan, Turkey, UK and the USA. We indeed find religious tradition differences. Hindus and scientists with no religious tradition are more likely to agree that commercialization of science “harms a university’s commitment to knowledge production” than Protestants. We end with a discussion on business ethics and the moral limits of the market as well as implications for entrepreneurs of contested commodities. (shrink)

Focused on the field of knowledge lying between digital and analog circuit theory, this new text will help engineers working with digital systems shorten their product development cycles and help fix their latest design problems. The scope of the material covered includes signal reflection, crosstalk, and noise problems which occur in high speed digital machines (above 10 megahertz). This volume will be of practical use to digital logic designers, staff and senior communications scientists, and all those interested in digital design.

This book offers the first sustained multi-disciplinary investigation of the question and status of ethics in light of the current "return to ethics" underway in a variety of critical fields. While the questions of ethics have become increasingly important in recent years for many fields within the humanities, there has been no single volume that seeks to address the emergence of this concern with ethics across the disciplinary spectrum. Given this lack in currently available critical and secondary texts, and also (...) the urgency of the issues addressed by the critics assembled here, the time is right for a collection of this nature. By assembling the work of nine critics from among these disciplines-including philosophy, women's studies, cultural studies, anthropology, literary studies, and history-this collection will help to frame the conversation on the status of ethics in the coming years. One of the great features of the book is the very high quality of work and the importance within the critical scene of many of its contributors. Contributors: Lowell Gallagher, Richard J. Golsan, David E. Johnson, Howard Marchitello, Kelly Oliver, Marshall Sahlins, Gayatri Chakravorty Spivak, Tzvetan Todorov, Krzysztof Ziarek. (shrink)

Skeptical theists argue that no seemingly unjustified evil (SUE) could ever lower the probability of God's existence at all. Why? Because God might have justifying reasons for allowing such evils (JuffREs) that are undetectable. However, skeptical theists are unclear regarding whether or not God's existence is relevant to the existence of JuffREs, and whether or not God's existence is relevant to their detectability. But I will argue that, no matter how the skeptical theist answers these questions, it is undeniable that (...) the skeptical theist is wrong; SUEs lower the probability of God's existence. To establish this, I will consider the four scenarios regarding the relevance of God's existence to the existence and detectability of JuffREs, and show that in each—after we establish our initial probabilities, and then update them given the evidence of a SUE—the probability of God's existence drops. (shrink)

This paper investigates whether the fundamental linguistic insights and intuitions of Lexical Functional Grammar, which is usually presented as a constraint-based linguistic theory, can be reformulated in a resource sensitive framework using a substructural modal logic. In the approach investigated here, LFG's f-descriptions are replaced with expressions from a multi-modal propositional logic. In effect, the feature structure unification basis of LFG's f-structures is replaced with a very different resource based mechanism. It turns out that some linguistic analyses that required non-monotonic (...) devices in LFG analysis of Icelandic) can be straightforwardly expressed in the framework presented here. Moreover, a Curry– Howard correspondence between proofs in this logic and -terms provides a semantic interpretation as a by-product of the process of showing syntactic well-formedness. (shrink)

David Johnson seeks to overthrow one of the widely accepted tenets of Anglo-American philosophy—that of the success of the Humean case against the rational credibility of reports of miracles. In a manner unattempted in any other single work, he meticulously examines all the main variants of Humean reasoning on the topic of miracles: Hume's own argument and its reconstructions by John Stuart Mill, J. L. Mackie, Antony Flew, Jordan Howard Sobel, and others. Hume's view, set forth in his (...) essay "Of Miracles," has been widely thought to be correct. Johnson reviews Hume's thesis with clarity and elegance and considers the arguments of some of the most prominent defenders of Hume's case against miracles. According to Johnson, the Humean argument on this topic is entirely without merit, its purported cogency being simply a philosophical myth. (shrink)

This book addresses several dimensions of the transformation of English Nonconformity over the course of an important century in its history. It begins with the question of education for ministry, considering the activities undertaken by four major evangelical traditions to establish theological colleges for this purpose, and then takes up the complex three-way relationship of ministry/churches/colleges that evolved from these activities. As author Dale Johnson illustrates, this evolution came to have significant implications for the Nonconformist engagement with its message (...) and with the culture at large. These implications are investigated in chapters on the changing perception or understanding of ministry itself, religious authority, theological questions, and religious identity.In Johnson's exploration of these issues, conversations about these topics are located primarily in addresses at denominational meetings, conferences that took up specific questions, and representative religious and theological publications of the day that participated in key debates or advocated contentious positions. While attending to some important denominational differences, The Changing Shape of English Nonconformity, 1825-1925 focuses on the representative discussion of these topics across the whole spectrum of evangelical Nonconformity rather than on specific denominational traditions.Johnson maintains that too many interpretations of nineteenth-century Nonconformity, especially those that deal with aspects of the theological discussion within these traditions, have tended to depict such developments as occasions of decline from earlier phases of evangelical vitality and appeal. This book instead argues that it is more appropriate to assess these Nonconformist developments as a collective, necessary, and deeply serious effort to come to terms with modernity and, further, to retain a responsible understanding of what it meant to be evangelical. It also shows these developments to be part of a larger schema through which Nonconformity assumed a more prominent place in the English culture of the nineteenth and early twentieth centuries. (shrink)

The main aim of this article is to describe central elements of, and the relationships among, three interrelated domains of inquiry. The first domain is Charles Peirce's semiotic theory which offers five concepts of special relevance to the other two domains: (a) primary components of the triadic sign, including the object, representamen, and interpretant; (b) the unceasing process of semiosis, or continuous growth of the developing sign; (c) the three forms of inference, of which Peirce's notion of abduction is of (...) special interest; (d) the element of surprise in experience, and (e) the universal categories of Firstness, Secondness, and Thirdness that ground Peirce's overarching theory. The second domain incorporates the discipline of psychosemiotics, which is defined as the study of how we learn, understand, and use the signs of culture. The article outlines the nature and scope of psychosemiotics and emphasizes its grounding in Peircean semiotics, meaning‐making, and the five concepts listed above. The claim will be made that signs, semiosis, and meaning act through the seven signways outlined in the article and thereby bind the individual into the surrounding physical and cultural environments. The third domain is formal education, for which implications are presented as derived from Peircean theory and viewed through the psychosemiotic lens. In this perspective, all forms of education are semiotic processes grounded in signs and meaning‐making. Further, formal education consists of learning a wide variety of culturally‐valued signs by way of the seven signways and through processes that often differ from a technocratic, standards‐driven, accountability‐oriented approach to learning and instruction. (shrink)

The main aim of this article is to describe central elements of, and the relationships among, three interrelated domains of inquiry. The first domain is Charles Peirce's semiotic theory which offers five concepts of special relevance to the other two domains: primary components of the triadic sign, including the object, representamen, and interpretant; the unceasing process of semiosis, or continuous growth of the developing sign; the three forms of inference, of which Peirce's notion of abduction is of special interest; the (...) element of surprise in experience, and the universal categories of Firstness, Secondness, and Thirdness that ground Peirce's overarching theory. The second domain incorporates the discipline of psychosemiotics, which is defined as the study of how we learn, understand, and use the signs of culture. The article outlines the nature and scope of psychosemiotics and emphasizes its grounding in Peircean semiotics, meaning‐making, and the five concepts listed above. The claim will be made that signs, semiosis, and meaning act through the seven signways outlined in the article and thereby bind the individual into the surrounding physical and cultural environments. The third domain is formal education, for which implications are presented as derived from Peircean theory and viewed through the psychosemiotic lens. In this perspective, all forms of education are semiotic processes grounded in signs and meaning‐making. Further, formal education consists of learning a wide variety of culturally‐valued signs by way of the seven signways and through processes that often differ from a technocratic, standards‐driven, accountability‐oriented approach to learning and instruction. (shrink)

One hundred and three participants solved conflict and non-conflict versions of four reasoning tasks using a two-response procedure: a base rate task, a causal reasoning task, a denominator neglect task, and a categorical syllogisms task. Participants were asked to give their first, intuitive answer, to make a Feeling of Rightness judgment, and then were given as much time as needed to rethink their answer. They also completed a standardized measure of IQ and the actively open-minded thinking questionnaire. The FORs of (...) both high- and low-capacity reasoners were responsive to conflict, such that FORs were lower for conflict relative to non-conflict problems. Consistent with the quantity hypothesis, high-capacity reasoners made a greater distinction between conflict and non-conflict items on measures of Type 2 thinking, namely, rethinking time and probability of changing answers. In contrast to the quality hypothesis, however, this rethinking time did not advantage the ability of the high-capacity group to produce normative answers, except for the base rate task. Indeed, we observed that the correlation between capacity and the probability of normative answers emerged at the initial response, rather than after rethinking. (shrink)

Social contract theory offers a powerful method and metaphor for the study of organizational ethics. This paper considers the variant of the social contract that has arguably gained the most attention among business ethicists: integrative social contracts theory or ISCT [Donaldson and Dunfee: 1999, Ties That Bind (Harvard Business School Press, Boston)]. A core precept of ISCT - that consent to membership in an organization entails obligations to follow the norms of that organization, subject to the moral minimums of basic (...) human rights - is a reasonable and appealing notion. One potential challenge for those attempting to apply this idea, however, lies in the dynamic nature of social norms. Organizational norms evolve, often through the conscious efforts of community members and leaders. As currently formulated, ISCT offers a framework that under-appreciates the evolving nature of moral norms. In this paper, we extend ISCT by considering the circumstances under which the terms of and parties to social contracts change. We also consider a number of principles that should be considered as the terms and parties to organizational social contracts change. (shrink)

This paper presents a new theory of modal reasoning, i.e. reasoning about what may or may not be the case, and what must or must not be the case. It postulates that individuals construct models of the premises in which they make explicit only what is true. A conclusion is possible if it holds in at least one model, whereas it is necessary if it holds in all the models. The theory makes three predictions, which are corroborated experimentally. First, conclusions (...) correspond to the true, but not the false, components of possibilities. Second, there is a key interaction: it is easier to infer that a situation is possible as opposed to impossible, whereas it is easier to infer that a situation is not necessary as opposed to necessary. Third, individuals make systematic errors of omission and of commission. We contrast the theory with theories based on formal rules. (shrink)

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Without systems of public, external symbols for recording information, nonliterate communities have to rely on human memory for the retention and transmission of cultural knowledge. Religious expressions either evolved in directions that rendered them memorable or they were--quite literally--forgotten. Most religious systems, including all of the great world religions, emerged among populations that were mostly illiterate (even if there was a literate elite). Thus, it should come as no surprise that religious systems and ritual systems, in particular, have evolved so (...) as to exploit variables that facilitate memory. No doubt, the invention of literacy ameliorates these variables' influence, however, the availability of such cultural tools neither eliminates that influence nor even surmounts it. Experimental psychologists have clarified variables that contribute to extraordinary recall for events that arise in the normal course of life. Probably, the most obvious is frequency. Experiencing events of the same type frequently aids memory for that type of event, though not necessarily for the details of any of the particular instances of that type. When Jains carry out the Puja ritual day after day, they become adept at its performance. Although they are fluent with the ritual's details, it is possible that they do not remember even one of their previous performances distinctively. (shrink)

This article will focus on the ethical issues of vaccine mandates and stake claim to the relatively extreme position that outright requirements for people to receive the vaccine are ethically correct at both the governmental and institutional levels. One novel strategy employed here will be to argue that deontological considerations pertaining to consent rights cut as much in favor of mandating vaccines as against them. The presumption seems to be that arguments from consent speak semi-definitively against forcing people to inject (...) something into their bodies, and so any argument in favor of mandates must produce different and overriding logical and ethical considerations. Our central claim will be that the same logic that might seem to prohibit vaccine mandates as violations of consent actually supports such mandates when viewed from the perspective of the potential bystander who might otherwise be exposed to COVID-19. (shrink)

We propose a new hybrid data mining method for predicting protein-protein interactions combining Likelihood-Ratio with rule induction algorithms. In essence, the new method consists of using a rule induction algorithm to discover rules representing partitions of the data, and then the discovered rules are interpreted as “bins” which are used to compute likelihood ratios. This new method is applied to the prediction of protein-protein interactions in the Saccharomyces Cerevisiae genome, using predictive genomic features in an integrated scheme. The results show (...) that the new hybrid method outperforms a pure likelihood ratio based approach. (shrink)

In this paper we argue that surgeons face a particular kind of within-role conflict of interests, related to innovation. Within-role conflicts occur when the conflicting interests are both legitimate goals of professional activity. Innovation is an integral part of surgical practice but can create within-role conflicts of interest when innovation compromises patient care in various ways, such as by extending indications for innovative procedures or by failures of informed consent. The standard remedies for conflicts of interest are transparency and recusal, (...) which are unlikely to address this conflict, in part because of unconscious bias. Alternative systemic measures may be more effective, but these require changes in the culture of surgery and accurate identification of surgical innovation. (shrink)

This paper considers the morally relevant ways in which population-based research is a distinct type of human subjects research that have unique moral considerations relevant for public health practitioners and researchers. By defining population-based research, the authors distinguish it from public health practice and then consider, in more detail, the ways in which population-based research differs from clinical human subjects research. Based upon the distinctions between these types of research and practice, they identify five important issues that arise in the (...) design and conduct of certain kinds of population-based research. The authors hope that public health practitioners find these distinctions useful in determining when their work may actually be population-based research and that public health researchers use them to identify the areas where ethical issues in their research may arise. (shrink)

In this paper, we will explore one way in which understanding can—and, we will argue, should—be valuable. We will do this by drawing on what has been said about the different ways knowledge can be valuable. Our main contribution will be to identify one heretofore undiscussed way knowledge could be valuable, but isn’t—specifically, having value to someone other than the understander. We suggest that it is a desideratum on an account of understanding that understanding have the specified type of value; (...) our basis for this claim will come from recent work in cognitive psychology. This desideratum can then be used to measure the success of various accounts of understanding. We argue that accounts of understanding that have a particular structure will predict why understanding has that sort of value. For good measure, we then engage in a bit of a literature review, investigating which extant accounts of understanding satisfy this desideratum. (shrink)